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The decrease in biofilm density as measured by the rate of change (ROC) was higher for the Gram-negative model compared with the Gram-positive model, but statistical significance was ascertained only for Intesti (p (p = 0.011). Methods Prospective study realized in the Matei Balș Institute between October 2015 – July 2016, including 55 patients diagnosed with sepsis.Conclusions By extrapolating our findings we hypothesize that phages may eventually represent an option for primary prophylaxis through coating of orthopedic prostheses and for secondary prophylaxis, by preventing osteomyelitis relapses through biofilm reduction when administered via local instillations. There were evaluated: number of SIRS criteria, primary sites of infection, incriminated germs, organ failures, septic metastases and there were calculated two scores of severity - APACHE (Acute Physiology and Chronic Health Evaluation), APS (Admission Point Score) and the estimated mortality rate. Results The study included 55 patients with a mean age of 57.9 years old and a sex ratio M: F = 1:1.75.One of the largest online dating apps for Mature singles on Facebook with over 25 million connected singles, First Met makes it fun and easy for mature adults to meet Mature people.Meet single Mature adults like you - whether you are a single parent, divorced, separated, or have never been married.The median optical density (OD) of staphylococcal culture decreased with 8.114 % (−9.386 %, 16.533 %) for the dilution 1/64 of Intesti, and 8.108 % (0.684 %, 20.143 %) for Pyo, respectively. Bacteriophage-driven inhibition of biofilm in Background Sepsis is a severe, life-threatening syndrome with high incidence and mortality rate, which needs a rapid diagnosis and severity evaluation in order to avoid fatal complications.The median OD decreased with 29.191 % (4.607 %, 48.448 %) for the dilution 1/2 of Intesti, and 35.555 % (6.122 %, 47.852 %) for Pyo, respectively. If the diagnosis has preset criteria (SOFA score more than 2), the prognosis remains an important problem in septic patients management.
Bergeron A17 Postoperative meningoencephalitis with XDR – a therapeutic challenge - Case report Cleo Nicoleta Roșculeț, Dalila-Ana Toma, Catrinel Ciuca, Daniela Tălăpan, Cătălin Apostolescu, Andrei Rogoz, Andrei Stangaciu, Viorica Mitescu, Tudor Vladoiu, Doina Iovănescu A18 Septic arthritis with Michaela Oana, Simona Costin A19 A novel approach for managing hard-to-treat infections Alina Cristina Neguț, Oana Săndulescu, Anca Streinu-Cercel, Maria Magdalena Moțoi, Mircea Ioan Popa, Adrian Streinu-Cercel A20 Nineteen months surveillance for multidrug resistant organisms (MDRO) by detecting asymptomatic colonization Daniela Tălăpan, Olga Mihaela Dorobăț, Mona Popoiu, Alexandru Mihai, Doina Iovănescu, Cleo Roşculeț, Cătălin Apostolescu, Gabriel-Adrian Popescu, Adrian Abagiu, Ruxandra Moroti-Constantinescu, Adriana Hristea, Victoria Aramă, Otilia Benea, Mădălina Simoiu, Rodica Bacruban, Adrian Streinu-Cercel, Alexandru Rafila A21 Antimicrobial resistance of Gram-positive cocci isolated from clinical specimens in the National Institute of Infectious Diseases “Prof Dr.Median age of patients with recurrent versus non-recurrent meningitis was 29 versus 57 years (p Background Bacteriophages are hypothesized to contribute to biofilm eradication through multiple actions, such as: 1) amplification in host cells; 2) production of depolymerizing enzymes that degrade the matrix of extracellular polymeric substances; 3) induction of depolymerizing enzymes in host cells; 4) infection of persistent bacterial cells and lysis upon reactivation .Methods We have performed an in vitro experiment in the National Institute for Infectious Diseases „Prof. Matei Balș”, assessing the influence on biofilm formation and biofilm eradication of commercially-available bacteriophage cocktails Intesti and Pyo (Eliava Bio Preparations, Tbilisi, Georgia) in different binary dilutions (1/2 through 1/64) as presented in Neguț et al., GERMS 2014.Whether you're Mature or just looking to meet Mature singles online, you can use our filters and advanced search to find single Mature women and men in your area who match your interests.And you can use our i Phone, Android, and Facebook dating apps to meet Mature singles on the go!